Activation of PPARδ stimulates utrophin A expression in skeletal muscle cells
نویسندگان
چکیده
منابع مشابه
Activation of PPARδ signaling improves skeletal muscle oxidative
245 words) 45 Background Exercise intolerance in heart failure has been linked to impaired 46 skeletal muscle oxidative capacity. Oxidative metabolism and exercise capacity 47 are regulated by PPARδ signaling. We hypothesized that PPARδ stimulation 48 reverts skeletal muscle oxidative dysfunction. 49 Methods Myocardial infarction (MI) was induced in C57BL/6 mice and the 50 development of ventri...
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Glucocorticoids are currently the only drug treatment recognized to benefit Duchenne muscular dystrophy (DMD) patients. The nature of the mechanisms underlying the beneficial effects remains incompletely understood but may involve an increase in the expression of utrophin. Here, we show that treatment of myotubes with 6alpha-methylprednisolone-21 sodium succinate (PDN) results in enhanced expre...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2007
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.21.6.a1301-d